Ischemia-Reperfusion Injury: Molecular Mechanisms of Pathogenesis and Methods of Their Correction

Abstract

Ischemia-reperfusion is a cascade of complex and interrelated pathological processes underlying many human diseases, including such socially significant as stroke, myocardial infarction, acute renal failure, etc. The present review considers modern ideas about the main biochemical and signal-regulatory processes occurring in the cell under conditions of ischemia-reperfusion. Both generally accepted and newly developed ways of ischemia-reperfusion lesion correction aimed at different chains of this pathological process are considered.