Association of Polymorphic Genome Variants in the 2q32.1 Locus with the Development of Vasovagal Syncope-Reference-Cited by-同舟云学术

Association of Polymorphic Genome Variants in the 2q32.1 Locus with the Development of Vasovagal Syncope

Published:2023-09-01 Issue:5 Volume:57 Page:827-832
ISSN:0026-8984
Container-title:Молекулярная биология
language:
Short-container-title:Molekulârnaâ biologiâ

Author:

Matveeva N. A.¹²,Titov B. V.¹²,Bazyleva E. A.¹,Kuchinskaya Е. А.¹,Kozin M. S.¹²,Favorov A. V.³,Pevzner A. V.¹,Favorova O. O.¹²

Affiliation:

1. National Medical Research Center for Cardiology named after academician E.I. Chazov, Ministry of Health of the Russian Federation

2. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation

3. Johns Hopkins School of Medicine

Abstract

Vasovagal syncope (VVS) is the most common form of syncope. The mechanisms of VVS development are not entirely clear. It is known that there is a genetic predisposition to this disease, but the data on the role of individual genes are quite contradictory. Recently, a genome-wide association study identified a locus at chromosome 2q32.1 associated with a united group of diseases – syncope and collapse; among the single nucleotide polymorphisms (SNPs) of this locus, the most significant association was observed for rs12465214. In a homogeneous sample of patients according to the diagnosis of VVS, we analyzed the association of rs12465214, rs12621296, rs17582219 and rs1344706 located on chromosome 2q32.1, with this form of syncope. In the enrolled set, only rs12621296 was associated with VVS by itself, whereas associations of other SNPs were observed only in biallelic combinations. An epistatic interaction between the components of the combination rs12621296*A + rs17582219*A was revealed. The possible involvement of individual genes localized in the 2q32.1 locus in the genetic architecture of the VVS is discussed.

Publisher

The Russian Academy of Sciences

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