Drug Resistance of Different Mycobacterium tuberculosis Genotypes in the Omsk Oblast, Russia-Reference-Cited by-同舟云学术

Drug Resistance of Different Mycobacterium tuberculosis Genotypes in the Omsk Oblast, Russia

Published:2024-08-28 Issue:2 Volume:93 Page:244-246
ISSN:0026-3656
Container-title:Микробиология
language:
Short-container-title:Microbiology

Author:

Vyazovaya A. A.¹,Kostyukova I. V.²,Gerasimova A. A.¹,Terentieva D. R.¹,Pasechnik O. A.³,Mokrousov I. V.¹

Affiliation:

1. St. Petersburg Pasteur Institute

2. Clinical Anti-tuberculosis Dispensary

3. Omsk State Medical University

Abstract

A total of 397 Mycobacterium tuberculosis strains isolated from newly diagnosed patients with pulmonary tuberculosis in the Omsk region in 2019‒2020 were genotyped. The prevalence of strains of the Beijing genotype (70.8%) was established, in particular of two clusters of the modern sublineage — Central Asian/Russian (46.1%) and B0/W148 (19.1%). Strains of the ancient sublineage of the Beijing genotype were represented by clusters 1071-32 and 14717-15, totaling 4.8%. Compared with other genotypes, B0/W148 cluster and the ancient Beijing sublineage were associated with multidrug resistance (MDR): 93.4% and 94.7%, respectively (P 0.0001). Among representatives of other genetic families (LAM, Ural, T, Haarlem), drug-sensitive strains predominated (75.0%). The circulation of MDR Beijing strains requires molecular epidemiological surveillance in view of their possible wider spread.

Publisher

The Russian Academy of Sciences

Reference11 articles.

1. Kostyukova I., Pasechnik O., Mokrousov I. Epidemiology and drug resistance patterns of Mycobacterium tuberculosis in High-Burden Area in Western Siberia, Russia // Microorganisms. 2023. V. 11. Art. 425. https://doi.org/10.3390/microorganisms11020425

2. Mokrousov I., Vyazovaya A., Pasechnik O., Gerasimova A., Dymova M., Chernyaeva E., Tatarintseva M., Stasenko V. Early ancient sublineages of Mycobacterium tuberculosis Beijing genotype: unexpected clues from phylogenomics of the pathogen and human history // Clin. Microbiol. Infect. 2019. V. 25. Art. 1039.e1–1039.e6. https://doi.org/10.1016/j.cmi.2018.11.024

3. Mokrousov I., Vyazovaya A., Shitikov E., Badleeva M., Belopolskaya O., Bespiatykh D., Gerasimova A., Ioannidis P., Jiao W., Khromova P., Masharsky A., Naizabayeva D., Papaventsis D., Pasechnik O., Perdigão J., Rastogi N., Shen A., Sinkov V., Skiba Y., Solovieva N., Tafaj S., Valcheva V., Kostyukova I., Zhdanova S., Zhuravlev V., Ogarkov O. Insight into pathogenomics and phylogeography of hypervirulent and highly-lethal Mycobacterium tuberculosis strain cluster // BMC Infect. Dis. 2023. V. 23. Art. 426.

4. https://doi.org/10.1186/s12879-023-08413-7

5. Mokrousov I., Vyazovaya A., Sinkov V., Gerasimova A., Ioannidis P., Jiao W., Khromova P., Papaventsis D., Pasechnik O., Perdigão J., Rastogi N., Shen A., Skiba Y., Solovieva N., Suffys P., Tafaj S., Umpeleva T., Vakhrusheva D., Yarusova I., Zhdanova S., Zhuravlev V., Ogarkov O. Practical approach to detection and surveillance of emerging highly resistant Mycobacterium tuberculosis Beijing 1071-32-cluster // Sci. Rep. 2021. V. 11. Art. 21392. https://doi.org/10.1038/s41598-021-00890-7