Behavioral activity of rats in experimental hyperotherosis, and its correction with iodine-containing preparations

Abstract

Investigated the behavioral activity of rats in experimental hypothyroidism and its correction with iodine-containing drugs. It has been established that with the introduction of mercazole thyreostatics for 8 weeks in white rats, experimental hypothyroidism develops. In which there was a decrease in the content of thyroxine (T4) to 5.25 ng / ml, an increase in the content of thyroid stimulating hormone (TSH) to 8.75 ng / ml, while in animals from the control (healthy) group, these indicators were: average T4 content 43.70 ng / ml; the average content of TSH is 1.73 ng / ml. Next, animals with iodine-containing preparations (Sedimin-Fe+, Sedimin-Se+) were administered to patients with experimental hypothyroidism as an intramuscular injection, 2 times with an interval of 10 days, and a bio-iron preparation with trace elements orally for 20 days. . So in the experimental groups that were injected drugs Sedimin-Fe+ and Sedimin-Se+ T4 value recovered to 52.7 ± 3.48 and 54.8 ± 4.17 ng / ml, respectively. In the group of the bio-iron with micronutrients receiving the feed, the T4 value reached 56.2 ± 4.13 ng / ml, while in sick animals this indicator was 5.25 ± 0.55 ng / ml. The value of TSH, after treatment with iodine-containing preparations, also returned to normal and after application of the drug Sedimin-Fe + 0.37 ± 0.14, Sedimin-Se + 0.51 ± 0.18 and Bio-iron with trace elements 0.47 ± 0.15 ng / ml, while in sick animals this indicator was 8.75 ± 0.55 ng / ml.