SYNERGISTIC EFFECT OF THE COMBINED ACTION OF TARGETED AND PHOTODYNAMIC THERAPY ON HER2-POSITIVE BREAST CANCER-Reference-Cited by-同舟云学术

SYNERGISTIC EFFECT OF THE COMBINED ACTION OF TARGETED AND PHOTODYNAMIC THERAPY ON HER2-POSITIVE BREAST CANCER

Published:2023-01-01 Issue:1 Volume:508 Page:48-52
ISSN:2686-7389
Container-title:Доклады Российской академии наук. Науки о жизни
language:
Short-container-title:Doklady Rossijskoj akademii nauk. Nauki o žizni

Author:

Balalaeva I. V.¹,Krylova L. V.¹,Karpova M. A.¹,Shulga A. A.²,Konovalova E. V.²,Guryev E. L.¹,Deyev S. M.²³

Affiliation:

1. Lobachevsky State University of Nizhny Novgorod

2. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

3. I.M. Sechenov First Moscow State Medical University

Abstract

Development of combined schemes for the treatment of oncological diseases is a promising strategy to improve the effectiveness of antitumor therapy. This paper shows the fundamental possibility of multiplying the antitumor effect by combining targeted and photodynamic therapy. It has been demonstrated that sequential treatment of HER-2 positive breast cancer cells with the targeted toxin DARPin-LoPE and the photoactive compound Photodithazine leads to a synergistic enhancement of their effect. In the future, this approach is intended to achieve the maximum therapeutic effect while minimizing the risks of negative side effects.

Publisher

The Russian Academy of Sciences

Reference19 articles.

1. Harbeck N., Penault-Llorca F., Cortes J., et al. // Nature Reviews Disease Primers. 2019. V. 5. № 66.

2. Gerber D.E. // American Family Physician. 2008. V. 77. № 3. P. 311–319.

3. Padma V.V. // Biomedicine (Taipei). 2015. V. 5. № 4. P. 19.

4. Iqbal N., Iqbal N. // Molecular Biology International. 2014.

5. Higgins M.J., Baselga J. // Journal of Clinical Investigation. 2011. V. 121. № 10. P. 3797–3803.

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