SYNTHESIS OF 1-[ω-(BROMOPHENOXY)ALKYL]-3-NAPHTHALENYLMETHYL DERIVATIVES OF URACIL AND THEIR ANALOGUES AS PROBABLE INHIBITORS OF HUMAN CYTOMEGALOVIRUS REPLICATION-Reference-Cited by-同舟云学术

SYNTHESIS OF 1-[ω-(BROMOPHENOXY)ALKYL]-3-NAPHTHALENYLMETHYL DERIVATIVES OF URACIL AND THEIR ANALOGUES AS PROBABLE INHIBITORS OF HUMAN CYTOMEGALOVIRUS REPLICATION

Published:2023-01-01 Issue:1 Volume:508 Page:35-40
ISSN:2686-7389
Container-title:Доклады Российской академии наук. Науки о жизни
language:
Short-container-title:Doklady Rossijskoj akademii nauk. Nauki o žizni

Author:

Paramonova M. P.¹,Gureeva E. S.¹,Ozerova A. A.¹,Snoeck R.²,Andrei G.²,Alexandrov D. A.³,Khandazhinskaya A. L.⁴,Novikova M. S.¹,Kochetkov S. N.⁴

Affiliation:

1. Volgograd State Medical University

2. Rega Institute for Medical Research, KU Leuven

3. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

4. V.A. Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences

Abstract

A new series of 1-[ω-(bromophenoxy) has been synthesizedalkyl]-uracil derivatives containing naphthalene-1-yl-, naphthalene-2-yl-, 1-brominaphthalene-2-ilmethyl, benzyl and anthracene-9-ilmethyl fragments in position 3 of uracil. Antiviral properties of synthesized compounds against human cytomegalovirus were studied. It was found that the compound, which has a bridge consisting of five methylene groups, has high anti-cytomegalovirus activity in vitro. uracil

Publisher

The Russian Academy of Sciences

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