SYNTHESIS OF 1-[ω-(BROMOPHENOXY)ALKYL]-3-NAPHTHALENYLMETHYL DERIVATIVES OF URACIL AND THEIR ANALOGUES AS PROBABLE INHIBITORS OF HUMAN CYTOMEGALOVIRUS REPLICATION-Reference-Cited by-同舟云学术

SYNTHESIS OF 1-[ω-(BROMOPHENOXY)ALKYL]-3-NAPHTHALENYLMETHYL DERIVATIVES OF URACIL AND THEIR ANALOGUES AS PROBABLE INHIBITORS OF HUMAN CYTOMEGALOVIRUS REPLICATION

Published:2023-03-01 Issue:1 Volume:509 Page:170-176
ISSN:2686-7389
Container-title:Доклады Российской академии наук. Науки о жизни
language:
Short-container-title:Doklady Rossijskoj akademii nauk. Nauki o žizni

Author:

Paramonova M. P.¹,Gureeva E. S.¹,Ozerov A. A.¹,Snoeck R.²,Andrei G.²,Aleksandrov D. A.³,Khandazhinskaya A. L.⁴,Novikov M. S.¹,Kochetkov S. N.⁴

Affiliation:

1. Volgograd State Medical University

2. Rega Institute for Medical Research, KU Leuven

3. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

4. Institute of Molecular Biology, Russian Academy of Sciences, V.A. Engelhardt RAS

Abstract

A synthesis of a new series of 1-[ω-(bromophenoxy)alkyl]-uracil derivatives containing in position 3 naphthalen-1-yl-, naphthalen-2-yl-, 1-bromonaphthalen-2-ylmethyl, benzyl, and anthracene 9-methyl fragment was carried out. The antiviral properties of the synthesized compounds were studied against human cytomegalovirus. It was found that the compound, which has in its composition a bridge consisting of five methylene groups, has a high anti-cytomegalovirus activity in vitro.

Publisher

The Russian Academy of Sciences

Reference23 articles.

1. Rodríguez-Goncer I., Fernández-Ruiz M., Aguado J.M. // Expert Rev. Anti. Infect. Ther. 2020. V. 18. P. 113–125.

2. Karrer U., Mekker A., Wanke K., Tchang V., Haeberli L. // Exp. Gerontol. 2009. V. 44. P. 689–694.

3. Jentzer A., Veyrard P., Roblin X., Saint-Sardos P., Rochereau N., Paul S., Bourlet T., Pozzetto B., Pillet S. // Microorganisms. 2020. V. 8. P. 1078.

4. Richardson A.K., Walker L.C., Cox B., Rollag H., Robin-son B.A., Morrin H., Pearson J.F., Potter J.D., Paterson M., Surcel H.M., Pukkala E., Currie M.J. // Clin. Transl. Oncol. 2020. V. 22. P. 585–602.

5. Lv Y.L., Han F.F., An Z.L., Jia Y., Xuan L.L., Gong L.L., Zhang W., Ren L.L., Yang S., Liu H., Liu L.H. // Intervirology. 2020. V. 63. P. 10–16.