HSPBP1 in complex with the peptide of the innate immunity protein TAG7 is able to lyse tumor cells carrying TNFR1 receptor-Reference-Cited by-同舟云学术

HSPBP1 in complex with the peptide of the innate immunity protein TAG7 is able to lyse tumor cells carrying TNFR1 receptor

Published:2024-07-05 Issue:1 Volume:514 Page:60-64
ISSN:2686-7389
Container-title:Доклады Российской академии наук. Науки о жизни
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Short-container-title:Doklady Rossijskoj akademii nauk. Nauki o žizni

Author:

Romanova E. A.¹,Yurkina D. M.¹,Yashin D. V.¹,Sashchenko L. P.¹,Georgiev G. P.¹

Affiliation:

1. Institute of Gene Biology of the Russian Academy of Sciences

Abstract

The search for new cytotoxic agents capable of lysing tumor cells is an important task in the fight against cancer. Here we have shown that the protein HspBP1, the chaperone of the heat shock protein Hsp70, is able to form a complex with the previously discovered peptide (17.1) of the innate immunity protein Tag7. Experiments using thermophoresis have demonstrated that the affinity of the Tag7 protein peptide 17.1 to the HspBP1 molecule is 100 times higher than that of the full-sized Tag7 molecule. The addition of the 17.1-HspBP1 complex to tumor cells induces apoptosis and necroptosis in them. The results obtained in this work can be used to develop promising antitumor drugs.

Publisher

The Russian Academy of Sciences

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