INTERACTOME OF PARAOXONASE PON2 REVEALS NEW PATHWAYS FOR TUMOR GROWTH REGULATION-Reference-Cited by-同舟云学术

INTERACTOME OF PARAOXONASE PON2 REVEALS NEW PATHWAYS FOR TUMOR GROWTH REGULATION

Published:2023-05-01 Issue:1 Volume:510 Page:236-242
ISSN:2686-7389
Container-title:Доклады Российской академии наук. Науки о жизни
language:
Short-container-title:Doklady Rossijskoj akademii nauk. Nauki o žizni

Author:

Karlov V. D.¹²,Pestov N. B.¹³⁴⁵,Shakhparonov M. I.¹,Korneenko T. V.¹

Affiliation:

1. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

2. All-Russia Research Institute of Agricultural Biotechnology

3. Moscow Institute of Physics and Technology

4. Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences

5. Institute of Biomedical Chemistry

Abstract

The interactome of paraoxonase-2 encoded by the PON2 gene was investigated. A cDNA library was screened using a yeast two-hybrid system to search for new proteins interacting with human PON2. Analysis of the identified candidates, along with previously published data on interactors obtained by other methods, indicates the presence of a significant number of indirect interactions between PON2 and EGFR and, consequently, possible regulation of tumor growth with mutant EGFR involving PON2.

Publisher

The Russian Academy of Sciences

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