<i>PRPF19</i> mRNA encodes a small open reading frame that is important for viability of human cells

Author:

Shepelev N. M.12,Kurochkina А. О.2,Dontsova О. А.134,Rubtsova M. P.12

Affiliation:

1. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

2. Lomonosov Moscow State University

3. A. N. Belozersky Institute of Physico-Chemical BiologyLomonosov Moscow State University

4. Skolkovo Institute of Science and Technology

Abstract

High-throughput ribosome profiling demonstrated the translation of thousands small open reading frames located in the 5′ untranslated regions of messenger RNAs (upstream ORFs). Upstream ORF can both perform a regulatory function by influencing the translation of the downstream main ORF, and encode a small functional protein or microprotein. In this work, we showed that the 5′ untranslated region of the PRPF19 mRNA encodes an upstream ORF that is translated in human cells. Inactivation of this upstream ORF reduces the viability of human cells.

Publisher

The Russian Academy of Sciences

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