COMBINED GAMMA-RAYS AND CARBON-12 NUCLEI IRRADIATION MODULATES BRAIN CHEMOKINE AND CYTOKINE PRODUCTION AND IMPROVES SPATIAL LEARNING IN TAU P301S, BUT NOT 5xFAD MOUSE LINE-Reference-Cited by-同舟云学术

COMBINED GAMMA-RAYS AND CARBON-12 NUCLEI IRRADIATION MODULATES BRAIN CHEMOKINE AND CYTOKINE PRODUCTION AND IMPROVES SPATIAL LEARNING IN TAU P301S, BUT NOT 5xFAD MOUSE LINE

Published:2023-07-01 Issue:1 Volume:511 Page:349-353
ISSN:2686-7389
Container-title:Доклады Российской академии наук. Науки о жизни
language:
Short-container-title:Doklady Rossijskoj akademii nauk. Nauki o žizni

Author:

Kokhan V. S.¹,Nesterov M. S.²,Levashova A. I.²

Affiliation:

1. V.P. Serbsky Federal Medical Research Centre for Psychiatry and Narcology

2. Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia,

Abstract

Earlier we showed the pro-cognitive effect of low doses of combined irradiation (including heavy charged particles) on Wistar rats. In the present work we studied the effect of irradiation (gamma-rays, 0.24 Gy; carbon-12, 0.18 Gy, 400 MeV/nucleon) on the course of neurodegenerative process using Tau P301S and 5xFAD transgenic mice lines, experimental models of Alzheimer’s disease. Irradiation led to an increase in pro- and anti-inflammatory cytokines and chemokines (IL-2, IL-6, IL-10, KC) in Tau P301S mice, but not in 5xFAD. At the same time, only the Tau P301S line was found to exhibit radiation-induced improvement in spatial learning.

Publisher

The Russian Academy of Sciences

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