GROWTH INDUCTION OF SOLID EHRLICH ASCITIC CARCINOMA IN MICE AFTER PROTON IRRADIATION OF TUMOR CELLS <i>EX VIVO</i>

Abstract

This study presents data on the growth rate and frequency of induction of the solid form of Ehrlich’s ascitic carcinoma (EAC) in mice in the short and long term after inoculation of ascitic cells irradiated ex vivo with a proton beam in the dose range of 30–150 Gy. It was shown that the growth rate of solid tumors after inoculation of irradiated cells ex vivo coincided with the growth of tumors in the control group. The frequency of tumor induction in mice after inoculation EAC cells irradiated at a dose of 30 Gy was 80%, 60 Gy – 60%, 90 Gy – 25%, 120 Gy – 10%, and with irradiation at a dose of 150 Gy, no tumors appeared during the entire observation period. Thus, we were able to determine the dose of proton radiation required to eliminate tumor cells and/or signaling factors that can lead to the induction of tumor growth of EAC in mice.