Role of BDNF in neuroplasticity associated with alcohol dependence-Reference-Cited by-同舟云学术

Role of BDNF in neuroplasticity associated with alcohol dependence

Published:2023-03-15 Issue:3 Volume:88 Page:491-507
ISSN:0320-9725
Container-title:Биохимия
language:
Short-container-title:Biohimiâ

Author:

Peregud D. I¹²,Baronets V. Yu¹,Terebilina N. N¹,Gulyaeva N. V²³

Affiliation:

1. Federal State Budgetary Institution, “V. Serbsky National Medical Research Center for Psychiatry and Drug Addiction” of the Ministry of Health of the Russian Federation

2. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences

3. Research and Clinical Center for Neuropsychiatry of Moscow Healthcare Department

Abstract

Chronic alcohol consumption is characterized by disturbances of neuroplasticity. Brain-derived neurotrophic factor (BDNF) may mechanistically participate in this process. Here we aimed to review actual experimental and clinical data related to BDNF involvement in neuroplasticity in the context of alcohol dependence. As shown in experiments on the rodents alcohol consumption is accompanied brain region-specific changes of BDNF expression and by structural and behavioral impairments. BDNF reverses aberrant neuroplasticity during alcohol intoxication. According to clinical data indices characterized BDNF demonstrate close relationship with consequences of alcohol dependence. Polymorphism rs6265 within BDNF gene interacts with macrostructural changes in the brain, while peripheral BDNF concentration may reflect anxiety, depression and cognitive decline. Thus, BDNF is involved in mechanisms of alcohol-related aberrant neuroplasticity, while polymorphisms within BDNF gene and peripheral BDNF concentration may be biomarkers, diagnostic or prognostic factors in clinics of alcoholism.

Publisher

The Russian Academy of Sciences

Reference77 articles.

1. Киржанова В. В., Григорова Н. И., Бобков Е. Н., Киржанов В. Н., Сидорюк О. В. (2021) Деятельность наркологической службы в Российской Федерации в 2019-2020 годах: Аналитический обзор, ФГБУ "НМИЦ ПН им. В.П. Сербского" Минздрава России, Москва.

2. The burden attributable to substance use in the Russian Federation

3. Alcohol and the brain: from genes to circuits

4. Alcohol and the Brain: Neuronal Molecular Targets, Synapses, and Circuits

5. Gilpin, N. W., and Koob, G. F. (2008) Neurobiology of alcohol dependence: focus on motivational mechanisms, Alcohol Res. Health, 31, 185-195.