Potential geroprotectors - from the banch to the clinic

Abstract

Geroprotectors are substances that slow down the aging process and can be used in the prevention of age-related diseases. Geroprotectors can improve the functioning of various organ systems and enhance their homeostatic capabilities. We have developed a system of criteria for geroprotectors and proposed their classification based on the mechanisms of action on the aging processes. It is necessary for geroprotectors to reduce mortality, improve human aging biomarkers, have minimal side effects, and enhance quality of life. Additionally, there are approaches based on combining geroprotectors targeted at different targets and mechanisms of aging to achieve maximum effectiveness. Currently, numerous preclinical studies are being conducted to identify new molecular targets and develop new approaches to extend healthy aging, although the number of clinical trials is limited. Geroprotectors have the potential to become a new class of preventive medicines as they prevent the onset of certain diseases or slow down their progression.