The role of Aurora B kinase in normal and cancer cells-Reference-Cited by-同舟云学术

The role of Aurora B kinase in normal and cancer cells

Published:2023-12-15 Issue:12 Volume:88 Page:2435-2445
ISSN:0320-9725
Container-title:Биохимия
language:
Short-container-title:Biohimiâ

Author:

Titova E. V¹,Shagieva G. S¹,Dugina V. B¹²,Kopnin P. B³

Affiliation:

1. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University

2. Faculty of Biology, Lomonosov Moscow State University

3. Institute of Carcinogenesis, Blokhin National Medical Research Centre of Oncology, Public Health Ministry of Russian Federation

Abstract

Aurora kinases are essential players in the process of mammalian cell division. Intracellular events in which Aurora kinases are involved include the regulation of spindle dynamics, microtubule-kinetochore interactions, chromosome condensation and orientation during mitosis. At least three members of the Aurora family - A, B and C - have been identified in mammals. Aurora B has been shown to be essential for maintaining genomic stability and normal cell division. Mutations and dysregulation of this kinase have been implicated in tumour initiation and progression. In this review, we discuss the functions of Aurora B, the relationship between increased Aurora B activity and carcinogenesis, and the prospects for the use of Aurora B kinase inhibitors in antitumour therapy.

Publisher

The Russian Academy of Sciences

Reference74 articles.

1. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

2. Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation

3. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles

4. Roles of Aurora Kinases in Mitosis and Tumorigenesis

5. Molecular Dynamics of Aurora-A Kinase in Living Mitotic Cells Simultaneously Visualized with Histone H3 and Nuclear Membrane Protein Importin.ALPHA..