Alzheimer’s Disease: A Search for the Best Experimental Models for the Decoding of the Cellular and Molecular Mechanisms of the Development of the Diease

Author:

Gorina Y. V.12,Vlasova O. L.1,Bolshakova A. V.1,Salmina A. B.123

Affiliation:

1. Laboratory of Molecular Neurodegeneration, the St. Petersburg Polytechnic University of Peter the Great

2. Research Institute of Molecular Medicine and Pathobiochemistry, Professor Voino-Yasenetsky Krasnoyarsk State Medical University

3. Laboratory of Neurobiology and Tissue Engineering, Brain Institute, Research Center of Neurology

Abstract

Alzheimer’s disease is the most common type of dementia associated with cognitive decline, such as memory and visuospatial skills. Insufficiently effective treatments have prompted the creation of experimental animal models capable of reproducing the pathology of Alzheimer’s disease, especially at the presymptomatic stage, in order to develop and study preventive and therapeutic strategies. To date, none of the developed animal models fully reflects the entire spectrum of neuropathological and cognitive impairments observed in the development of Alzheimer’s disease in humans. However, each model created allows, to one degree or another, to study various aspects of the pathogenesis of the disease, providing an important understanding of the key pathological changes that may occur during its development. In this review, we present a summary of the neuropathological features of Alzheimer’s disease and their relationship to cognitive impairment in the animal models currently in use. We also present in a comparative aspect the features of the development of Alzheimer’s type neurodegeneration using the example of 2 models – genetic and injection, which will make it possible to determine optimal approach when choosing a model for implementing research tasks.

Publisher

The Russian Academy of Sciences

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