The Effect of Spinal Cord Injury on P2 Signaling in the Cholinergic Synapse-Reference-Cited by-同舟云学术

The Effect of Spinal Cord Injury on P2 Signaling in the Cholinergic Synapse

Published:2023-05-01 Issue:5 Volume:109 Page:588-599
ISSN:2658-655X
Container-title:Российский физиологический журнал им И М Сеченова
language:
Short-container-title:Rossijskij fiziologičeskij žurnal im. I.M. Sečenova

Author:

Khairullin A. E.¹²,Efimova D. V.¹,Eremeev A. A.²,Sabirova D. E.²,Grishin S. N.¹,Ziganshin A. U.¹

Affiliation:

1. Kazan State Medical University

2. Kazan Federal University

Abstract

It is known that in spinal motor neurons, after damage to the upper level of the spinal cord, neuronal degradation occurs, accompanied by axon degeneration. In the present study, the functional integrity of neuromuscular transmission was assessed by the method of stimulation mechanomiography. We demonstrated a decrease in the modulating activity of ATP in the cholinergic synapse due to spinal cord injury (a model of spinal cord contusion injury) in comparison with hypodynamia (a model of anti-orthostatic hanging of the hind limbs). The demonstrated abnormal modulation of the neuromuscular junction by purines provides evidence of axon degeneration and suggests that trans-synaptic degeneration of motor neurons may occur below the level of spinal cord injury in patients with similar injuries.

Publisher

The Russian Academy of Sciences

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