Association of VNTR Polymorphism of the <i>AS3MT</i> Gene with the Risk of Schizophrenia-Reference-Cited by-同舟云学术

Association of VNTR Polymorphism of the <i>AS3MT</i> Gene with the Risk of Schizophrenia

Published:2023-04-01 Issue:4 Volume:59 Page:481-486
ISSN:0016-6758
Container-title:Генетика
language:
Short-container-title:Genetika

Author:

Korovaitseva G. I.¹,Lezheiko T. V.¹,Oleichik I. V.¹,Golimbet V. E.¹

Affiliation:

1. Mental Health Research Centre

Abstract

The AS3MT gene encodes arsenic(III) methyltransferase. VNTR polymorphism of the AS3MT gene is characteristic only for the human genome. It is associated with the expression of a human-specific AS3MTd2d3 protein isoform, which is a potential risk factor for the development of schizophrenia. In this study, we for the first time have analyzed the distribution of frequencies of alleles and genotypes of VNTR polymorphism in a large sample of ethnic Russians. The association of VNTR with the risk of schizophrenia has been studied. The study included 1002 patients with schizophrenia and schizophrenia spectrum disorders and 1510 people of the control group. Women with the V3/V3 genotype have an increased risk of schizophrenia (OR = 1.4, 95% CI: 1.11–1.77).

Publisher

The Russian Academy of Sciences

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