Toll-like receptor gene polymorphisms in a population-based study of HIV and tuberculosis patients from Eastern Europe and Central Asia-Reference-Cited by-同舟云学术

Toll-like receptor gene polymorphisms in a population-based study of HIV and tuberculosis patients from Eastern Europe and Central Asia

Published:2024-09-11 Issue:4 Volume:60 Page:84-93
ISSN:0016-6758
Container-title:Генетика
language:
Short-container-title:Genetika

Author:

Salamaikina S. А.¹²,Korchagin V. I.¹,Mironov К. О.¹,Kulabukhova Е. I.¹³,Zimina V. N.⁴,Kravtchenko А. V.¹

Affiliation:

1. Central Research Institute of Epidemiology Federal service for surveillance on consumer rights protection and human wellbeing

2. Moscow institute of physics and technology

3. Peoplesʹ Friendship University of Russia (RUDN University)

4. Kemerovo state medical university of the ministry of health of the Russian Federation

Abstract

Genetic diversity of human populations is determined by polymorphic variants of immune response genes and can be linked to the variation in responses to infectious agents. This study compared allele and genotype frequencies of polymorphic variants of TLR1, TLR2, TLR4, TLR6 and TLR8 genes between samples from Eastern Europe and Central Asia. We included 680 unrelated individuals from Eastern Slavic (n = 308), Armenian (n = 137), Tajik (n = 138) and Kyrgyz (n = 97) samples of patients with confirmed diagnoses of HIV and tuberculosis. The international 1000 Genomes Project data - samples of Caucasians (EUR) and countries of eastern (EAS) and southern (SAS) Asia – were used for comparison. Despite the lack of genetic diversity and population differences in allele frequencies of the analyzed genes, the samples differed in a number of loci both from each other and from EAS, SAS samples.

Publisher

The Russian Academy of Sciences

Reference41 articles.

1. Саламайкина С.А., Миронов К.О. Однонуклеотидные полиморфизмы генов толл-подобных рецепторов, ассоциированные с риском развития туберкулеза и другими заболеваниями нижних дыхательных путей // Эпидемиология и инфекционные болезни. Актуальные вопросы. 2023. Т. 4. С. 57–61.

2. Naderi M., Hashemi M., Mirshekari H. et al. Toll-like receptor 1 polymorphisms increased the risk of pulmonary tuberculosis in an iranian population sample // BES. 2016. V. 29. № 11. P. 825–828. https://doi.org/10.3967/bes2016.110

3. Thompson C.M., Holden T.D., Rona G. et al. Toll-like receptor 1 polymorphisms and associated outcomes in sepsis after traumatic injury: А candidate gene association study // Annals of Surgery. 2014. V. 259. № 1. P. 179–185. https://doi.org/10.1097/SLA.0b013e31828538e8

4. Schurz H., Daya M., Möller M. et al. TLR1, 2, 4, 6 and 9 variants associated with tuberculosis susceptibility: А systematic review and meta-analysis // PLoS One. 2015. V. 10. https://doi.org/10.1371/journal.pone.0139711

5. Gao J., Zhang A., Wang X. et al. Association between the TLR2 Arg753Gln polymorphism and the risk of sepsis: a meta-analysis // Critical Care. 2015. V. 19. № 1. P. 416. https://doi.org/10.1186/s13054-015-1130-3