Affiliation:
1. Institute of Biology and Chemistry Moscow Pedagogical State University
2. Koltzov Institute of Developmental Biology of Russian Academy of Sciences
Abstract
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor and its target genes play a fundamental role in detoxification, regulation of developmental processes, maintenance of homeostasis, as well as in the occurrence of oncological and autoimmune diseases and drug metabolism. The high conservatism of vertebrate AHR allowed us to study its functions in vivo using transformed Drosophila melanogaster fruit flies with human or mouse AHR gene and compare the ectopic effect of their expression with the expression of spineless gene, Drosophila AHR homologue. This work demonstrates for the first time that vertebrate AHR exhibits its functional activity in Drosophila embryogenesis, in leg imaginal discs and in somatic cells of female reproductive system in the absence of exogenous ligands.
Publisher
The Russian Academy of Sciences
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