Synthesis, Structure, and Properties of the Iron Nitrosyl Complex with 2-Ethyl-4-pyridinecarbothioamide-Reference-Cited by-同舟云学术

Synthesis, Structure, and Properties of the Iron Nitrosyl Complex with 2-Ethyl-4-pyridinecarbothioamide

Published:2023-09-01 Issue:9 Volume:49 Page:530-542
ISSN:0132-344X
Container-title:Координационная химия
language:
Short-container-title:Koordinacionnaâ himiâ

Author:

Sanina N. A.¹²³,Shilov G. V.¹,Ovanesyan N. S.¹,Mumyatova V. A.¹,Balakina A. A.¹,Terent’ev A. A.¹²³,Pokidova O. V.¹,Aldoshin S. M.¹

Affiliation:

1. Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia

2. Research and Education Center “Medicinal Chemistry” in Chernogolovka, State University of Education, Mytishchi, Moscow oblast, Russia

3. Moscow State University, Moscow, Russia

Abstract

The synthesis and data on the physicochemical characteristics and biological activity of the newiron nitrosyl complex (Q+)2[Fe2(S2O3)2(NO)4]2– (I), where Q+ is protonated 2-ethyl-4-pyridinecarbothioamide(C8H11N2S), are presented. The structure and properties of the complex were studied by X-ray diffraction,elemental analysis, IR and Mössbauer spectroscopy, and amperometry. The complex showed antibacterialactivity and efficiently inhibited cyclic guanosine monophosphate phosphodiesterase (cGMP PDE),which may suggest its antihypertensive, anti-aggregation, and vasodilator activities.

Publisher

The Russian Academy of Sciences

Reference71 articles.

1. Benencia F., Courreges M.C. // Immunology.1999. V. 98. № 3. P. 363.

2. Mehta D.R., Ashkar A.A., Mossman K.L. // PLoS One. 2012. V. 7. № 2. Art. e31688.

3. McMullin B.B., Chittock D.R., Roscoe D.L. et al. // Respiratory Care. 2005. V. 50. № 11. P. 1451.

4. Jones-Carson J., Zweifel A.E., Tapscott T. et al. // PLoS Negl. Trop. Dis. 2014. V. 8. № 8. Art. e3079.

5. Fang F.C. // J. Clin. Invest. 1997. V. 99. № 12. P. 2818.