Affiliation:
1. Nesmeyanov Institute of Organic Element Compounds, Russian Academy of Sciences
2. Moscow Institute of Physics and Technology (National Research University)
3. Mendeleev University of Chemical Technology of Russia
Abstract
Biocompatible metal-organic framework MIL-100(Fe) was used as a container for a model hydrophobic active pharmaceutical ingredient, ibuprofen, in composite films based on gelatin, pectin, and kappacarrageenan. According to powder X-ray diffraction and scanning electron microscopy data, the metal-organic framework retained the crystal structure and its particles were uniformly distributed throughout the hydrocolloid matrix. Testing of the obtained film materials under simulated biological conditions using chromatography – mass spectrometry analysis showed that they are applicable as a dosage form for slow release of active pharmaceutical ingredients.
Publisher
The Russian Academy of Sciences