Hybrid antimicrobial coating based on conjugate of hyaluronic acid with peptide LL-37 for PEO-modified titanium implants-Reference-Cited by-同舟云学术

Hybrid antimicrobial coating based on conjugate of hyaluronic acid with peptide LL-37 for PEO-modified titanium implants

Published:2024-04-15 Issue:2 Volume:50 Page:
ISSN:1998-2860
Container-title:Биоорганическая химия
language:
Short-container-title:RUBI

Author:

Parfenova L. V.¹,Galimshina Z. R.¹,Gil’fanova G. U.¹,Alibaeva E. I.¹,Pashkova T. M.²,Kartashova O. L.²,Farrakhov R. G.³,Aubakirova V. R.³,Parfenov E. V.³

Affiliation:

1. Institute of Petrochemistry and Catalysis of Russian Academy of Sciences

2. Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

3. Ufa University of Science and Technology

Abstract

A conjugate of hyaluronic acid and antimicrobial peptide LL-37 was synthesized for the first time. The hybrid compound was tested as an antimicrobial organic coating for titanium samples with an inorganic sublayer obtained by plasma electrolytic oxidation (PEO) of the surface. As a result of in vitro studies, the antibacterial effect of the hybrid molecule within the inorganic PEO coating was established, which consists of a significant (p 0.05) suppression of the ability of Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecium and Escherichia coli to form biofilms. The presented approach can be utilized for the subsequent design and development of non-fouling antimicrobial coatings to decrease the risk of infectious diseases caused by bacteria when using implants.

Publisher

The Russian Academy of Sciences

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