Affiliation:
1. Institute of Cell Biophysics, Russian Academy of Sciences
2. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Abstract
A study has been made on the effects of sodium diethyldithiocarbamate and melatonin and their interaction on proliferative activity, the variation in cytosolic Ca2+, membrane potential and reactive oxygen species production in the neuroblastoma N1E-115 cell line (a clone of cells from mouse neuroblastoma C-1300). This study showed that combined use of diethyldithiocarbamates and melatonin inhibited proliferation and enhanced cell differentiation. At the same time, the content of Bcl-2 decreased, while the content of Bax increased, that were likely to trigger an apoptotic cascade. However, the use of these two drugs in combination did not enhance the observed effects. Therefore, this study suggests that the mechanisms by which diethyldithiocarbamates and melatonin act are apparently different.
Publisher
The Russian Academy of Sciences