Pathogenetic mechanisms of burn disease associated with oxidative membrane damage and ways of their correction

Abstract

Despite significant progress in the treatment of burn disease, mortality in this pathology can exceed 50% owing to the development of multiple organ dysfunction syndrome when more than 30% of the body surface area is affected. The review describes the most important molecular and biological mechanisms that underlie the development of multiple organ dysfunction syndrome in which free-radicals cause damage to plasma membranes, mitochondria, damaged mitochondria generate other free radicals, mitochondrial DNA is modified and used as a trigger of inflammatory processes in peripheral organs and systems. Secondary changes in the system of lipid transport in the blood and their role in generalization of multiple organ failure and hormonal imbalance are considered. In view of pathogenic metabolic shifts, use of antioxidants (such as quinones) in combination with lipid metabolism modulators is a reasonable strategy to reduce the activity of the inflammatory process and hormonal imbalance in the treatment of burn disease.