Affiliation:
1. Russian Research Institute of Hematology and Transfusiology
2. St.-Petersburg State University
Abstract
The influence of perfluorocarbon (PFС) nanoparticles on functioning of blood cells is considered. Emulsified PFC nanoparticles in small volumes affect the gas transport function of the blood by increasing the rate of oxygen diffusion from erythrocytes to tissues. PFC nanoparticles were found to affect blood cells (erythrocytes, leukocytes, platelets) in a dose-dependent manner. It is assumed that depending on the emulsion dose, i.e., the density of nanoparticles in the surrounding milieu, the response of the cell receptor apparatus can cause activation or deterioration of the cell functioning.
Publisher
The Russian Academy of Sciences
Reference34 articles.
1. Riess J.G., Flaim S.F., Klein D.H., Weers J.G. 1995. The relative physicochemical and biological atrtributes of perflubron emulsions. В сб.: Физиологическая активность фторсодержащих соединений (эксперимент и клиника). Ред. Воробьев С.И., Иваницкий Г.Р. Пущино, с. 73–90.
2. Coch C.S., Cushing M.M. 2009. Oxygen therapeutics: Perfluorocarbons and blood substitute safety. Crit. Care Clin. 25, 399–414. https://doi.org/1016/j/ccc. 2008.12.007
3. Henkel-Hanke T., Oleck M. 2007. Artificial oxygen carriers: A current review. Am. As. Nurse Anest. J. 75 (3), 205–211.
4. Маевский Е.И., Аксёнова О.Г., Богданова Л.А., Иваницкий Г.Р. 2004. Анализ побочных клинических эффектов, выявленных в ходе I–II фазы клинических исследований Перфторана. Вестник службы крови России. (4), 23–29.
5. Vercellotti G.M., Hammerschmidt D.E., Craddock P.R., Jacob H.S. 1982. Activation of plasma complement by perfluorocarbon artificial blood: Probable mechanism of adverse pulmonery reactions in treated patients and rationale corticosteroids prophylaxis. Blood. 59, 1299–1304.