Affiliation:
1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
2. Research Institute of Clinical and Experimental Lymрhology — Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Abstract
In this work, the properties of gel materials based on collagen and derivatives of taxifolin, pentaglutarate of taxifolin, and conjugate of taxifolin with glyoxylic acid were studied. It was shown that the increase in the proportion of the polyphenols in a gel led to the decrease in the rate of degradation of the materials. The materials had no negative impact on the viability of NIH/3T3 cells. The cells attached to the surface of the materials. Moreover, it was shown that they spread to the surface of the material containing pentaglutarate of taxifolin. It was also found that fibroblast migrated throughout the materials. An increase in the proportion of conjugate of taxifolin with glyoxylic acid in a material led to a decrease in cell migration throughout the material, whereas an increase in the proportion of pentaglutarate of taxifolin in a material led to a significant increase in cell migration throughout the material. The obtained data suggest that new materials for regenerative medicine can be derived from collagen and taxifolin derivatives.
Publisher
The Russian Academy of Sciences
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