Epidemiological, cellular, genetic and epigenetic aspects of biosafety-Reference-Cited by-同舟云学术

Epidemiological, cellular, genetic and epigenetic aspects of biosafety

Published:2024-08-15 Issue:3 Volume:94 Page:287-298
ISSN:0869-5873
Container-title:Вестник Российской академии наук
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Short-container-title:Vestnik Rossijskoj akademii nauk

Author:

Akimkin V. G.¹,Zverev V. V.²³,Kirpichnikov M. P.⁴⁵,Sverdlov E. D.⁶,Starodubov V. I.⁵⁷,Yankovskyd N. K.⁸⁴

Affiliation:

1. Central Research Institute for Epidemiology

2. I.I. Mechnikov Research Institute of Vaccines and Serums

3. I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

4. M.V. Lomonosov Moscow State University

5. The Russian Academy of Sciences

6. Research Center “Kurchatov Institute”

7. Central Research Institute for Organization and Informatization of Healthcare of the Ministry of Health of the Russian Federation

8. N.I. Vavilov Institute of General Genetics

Abstract

Currently, the problem of biological safety is extremely relevant for all countries of the world due to the expansion of the spectrum of real and potential threats caused by exposure to dangerous agents of biological nature. The pandemic of the new coronavirus infection has clearly demonstrated its vulnerability to the world. The inevitability of the occurrence of future epidemics necessitates the introduction of scientific developments in the field of creation and improvement of methods for amplification of nucleic acids, identification of pathogens using next-generation sequencing, genome editing technologies, etc. It seems advisable to study the reactions of the immune system to recombinant microorganisms containing genes for stimulators of the innate immune response in order to develop platforms for the creation of universal vaccines active against a wide range of pathogens. Based on the analysis of genomes and transcriptomes, it is possible to identify targets (including RNA targets destroyed by RNA interference) that are most promising for the treatment and prevention of new and recurring infectious diseases. The development of an integrated approach to the implementation of the genomic and epigenomic epidemiological surveillance system, taking into account the latest achievements of fundamental research in the field of virology, immunology, and biotechnology, will make a significant contribution to ensuring the biological safety of the Russian Federation.

Publisher

The Russian Academy of Sciences

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