NATIVE STRAINS OF HUMAN INTESTINAL BIFIDOBACTERIA: INDIGENEITY THROUGH THE PRISM OF PERSISTENCE

Abstract

The indigenous human microbiota is a natural storehouse of bifidobacteria strains, the key to our health. Todetermine the indigeneity of symbiont microorganisms, it is proposed to evaluate their adaptive potential (lysozyme resistance and biofilm formation), since adaptation is characteristic of all living systems, and in the human body the main adaptation strategy for bacteria is persistence. One of the mechanisms of persistence of indigenous bifidoflora is resistance to the action of host lysozyme, realized through the modification of peptidoglycan – O-acetylation (a wide range of O-cetylate determinants and a family of σ-factors). An important function of indigenous bifidobacteria in the functioning of the human digestive tract is their ability to participate in microbial recognition of “friend or foe”. The results obtained made it possible to open access to a source of beneficial indigenous microorganisms and use them in the selection of cultures for the creation of modern biological products.