Formation of Various Antimicrobial Peptide Emericellipsin Isoforms in <i>Emericellopsis alkalina</i> under Different Cultivation Conditions-Reference-Cited by-同舟云学术

Formation of Various Antimicrobial Peptide Emericellipsin Isoforms in <i>Emericellopsis alkalina</i> under Different Cultivation Conditions

Published:2023-03-01 Issue:2 Volume:59 Page:174-181
ISSN:0555-1099
Container-title:Прикладная биохимия и микробиология
language:
Short-container-title:Prikladnaâ biohimiâ i mikrobiologiâ

Author:

Kuvarina A. E.¹,Sukonnikov M. A.¹,Rogozhin E. A.¹²,Serebryakova M. V.³,Timofeeva A. V.³,Georgieva M. L.¹⁴,Sadykova V. S.¹

Affiliation:

1. Gause Institute New Antibiotics

2. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

3. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University

4. Lomonosov Moscow State University

Abstract

A microbiological screening of the target component of emericellipsin A of the Emericellopsis alkalina E101 strain was carried out in various biotechnological systems at various pH. The content of emericellipsin A was quantified under these conditions.It has been established that the new approved membrane-liquid cultivation method at pH 10 contributes to an increase in the yield of the main component of emericellipsin A. It was shown that the new method of cultivating the strain E. alkalina E101 also promotes the synthesis of various isoforms of the main component of emericellipsin A. Some comparative analysis of them was carried out.

Publisher

The Russian Academy of Sciences

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