Features of Changes in Exogenous Heat Shock Proteins (HSP 27 and HSP 70) in Patients with Occupational Nervous System Pathology

Abstract

The aim of the study was to identify and compare changes in serum concentrations of heat shock proteins (HSP 27 and HSP 27) in patients with occupational nervous system pathology induced by exposure to physical and chemical factors. Patients with sensorineural hearing loss (SHL), chronic mercury intoxication (CMI), vibration disease (VD) formed both under the influence of local vibration and combined exposure to general and local vibration were examined. As a result of comparative evaluation and analysis of serum concentrations of heat shock proteins, peculiarities in their change were revealed. In individuals with SHL and VD due to local vibration exposure, a decrease in serum HSP 70 concentration was recorded, and in patients with CMI and VD due to combined local and general vibration exposure, high HSP 27 concentrations were recorded. The examination of patients in the linked sample at 3 years showed the absence of statistically significant differences and the preservation of changes in the content of exogenous HSPs, which confirms the progressive course of these diseases. The conjugation of the number of T-lymphocyte and B-cells subpopulations with the change in serum HSP concentrations was established, which confirms the role of HSP 27 and 70 in the regulation of the immune response in VD and allows them to be regarded as markers of cellular and tissue damage in the chronic course of diseases.