Randomized multihit models and their identification

Abstract

The multihit–one target model induces a stochastic ordering of cell survival with respect to the cell sensitivity characteristics. This property can be used for a description of cell killing effects in heterogeneous populations of cells on the basis of randomized versions of the model. In such versions, either the critical number of lesions or the mean number of hits per unit dose (sensitivity), or both, are assumed to be random. We give some new results specifying conditions under which the randomized multihit models are identifiable, with a focus on the following cases: (1) the critical number of radiation-induced lesions, m, is random; (2) the sensitivity parameter, x, is random given m is known or otherwise; (3) x and m form a pair of independent random variables.