The geometry of random drift II. The symmetry of random genetic drift

Abstract

It has been conjectured that a certain transformation of gene frequency space due to Fisher and Bhattacharyya will map the random genetic drift process, or its diffusion approximation, into one with radial symmetry. This paper proves rigorously that the Fisher–Bhattacharyya mapping does not do this. This implies that the initial state of an evolving ensemble can only be unbiasedly estimated from the means of a sample if we weight by the proper divergence times. If the ensemble is known not to have begun at the centroid of frequency space, the estimate of the initial state vector is not simply the arithmetic average, as symmetry analysis of the Christoffel velocity field shows.