Author:
Flowers R.H.,Torner James C.,Farr Barry M.
Abstract
Abstract
A meta-analysis of six controlled studies was performed to evaluate the
risk of cytomegalovirus (CMV) infection among pediatric nurses. The pooled
risk ratio for CMV infection in pediatric nurses using cumulative incidence
data was statistically significant (risk ratio [RR] 2.7; 95% confidence
interval [CI] 1.33 - 5.52), but person-year analysis taking account of
follow-up periods demonstrated a trend toward increased risk that failed to
reach statistical significance (RR 1.8; 95% CI 0.88 - 3.55). Despite
pooling, there was low statistical power for comparing person-year rates.
The studies included in this analysis failed to provide data on several
potential confounding variables. We conclude that studies published prior to
the widespread adoption of universal precautions suggest that pediatric
nurses may have been at increased risk for CMV infection due to occupational
exposure, but inadequate design and sample size of the studies prevent a
definitive conclusion. Well-designed, controlled studies are still needed to
define the occupational risk of CMV infection.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Microbiology (medical),Epidemiology
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