Overcoming Tagraxofusp-Erzs Monotherapy Resistance in Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) in a Real-World Clinical Setting

Author:

Dhakal Prajwal12ORCID,Sy Mario12,Sutamtewagul Grerk12,Mou Eric12,Yu Nanmeng12,Pemmaraju Naveen3

Affiliation:

1. 1 Department of Internal Medicine, Division of Hematology, Oncology, and Blood & Marrow Transplantation, University of Iowa Carver College of Medicine, Iowa City, IA, USA

2. 2 Holden Comprehensive Cancer Center, University of Iowa Carver College of Medicine, Iowa City, IA, USA

3. 3 Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA

Abstract

ABSTRACT Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and clinically aggressive hematologic malignancy with limited treatment options. Currently, standard treatment strategies include clinical trials; chemotherapy regimens such as hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (HCVAD); and tagraxofusp-erzs (TAG, previously SL-401) which is the first-in-class targeted therapy against CD123. TAG received Food and Drug Administration approval for frontline BPDCN treatment in December 2018 and has increasingly become an alternative to chemotherapy, offering potentially more effective and less toxic options. However, despite promising results, there are still patients who may be resistant to TAG monotherapy and/or who respond but eventually relapse. Herein, we discuss an important patient case of BPDCN treated with TAG and review BPDCN treatment strategies.

Publisher

Innovative Healthcare Institute

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