A New Synthesis of Crown Ether-Based Methyl 4,6-Benzylidene-2,3-Di-O-Benzyl-a-D-Glucopyranosides Ethers as Anticancer Agents

Abstract

This study focuses on the synthesis and characterization of Aza and Thia Crown Ether-Based Methyl a-D-glucopyranosides using a phase transfer catalysis method. Characterization involved Fourier transform infrared, 1H NMR, and 13C NMR spectroscopy. The study also evaluated the anticancer potential of these compounds against PC3 (prostate cancer cells) and WRL68 (normal liver cells). Compound 12 exhibited a more significant effect on PC3 cells compared to compound 11. At the highest concentration (400 ?M), compound 12 demonstrated a mean inhibition of 95.72% in PC3 cells, while compound 11 showed a mean inhibition of 33.29% at the same concentration. Furthermore, the IC50 value for compound 12 in PC3 cells was 112.9 ?M, whereas compound 11 had an IC50 value of 24.38 ?M, indicating that compound 11 is less effective in inhibiting PC3 cell growth. These findings suggest that compound 12 may have greater potential as a therapeutic agent for prostate cancer.. KEYWORDS :Anticancer potential, Aza, Crown Ether-Based Methyl a-D-glucopyranosides, Cyclic peptides, Normal liver cells, Prostate cancer cells.