Synthesis of Some New Schiff Base Derivatives of Simazine and Atrazine for In Vitro Antimycobacterial Activity

Abstract

This study presents the design and synthesis of some new Schiff base derivatives of simazine and atrazine series for in vitro antitubercular activity. The synthesis of target compounds 5a-h/6a-h was accomplished in two steps starting from simazine (1) and atrazine (2). The first common step involved nucleophilic substitution with 4-aminoacetophenone to give the corresponding 4-substituted derivatives 3/4. The obtained intermediates were subsequently converted to Schiff basses by reacting with various amines. The synthesized compounds were evaluated for potential medicinal properties against tuberculosis, with findings indicating that introducing specific substituents onto the s-triazine ring enhanced their antimycobacterial activity. Compounds featuring amine derivatives with alkyl and methoxy groups demonstrated the highest efficacy. These modified structures serve as promising templates for developing molecules effective against various pathogenic microorganisms, contributing to the drug discovery process for infectious disease treatment.. KEYWORDS :Antimycobacterial activity, Atrazine, Schiff base, Simazine, s-Triazine.