Association of body mass index with clinical outcomes in patients with acute coronary syndrome: A systematic review and meta-analysis

Abstract

Background: In this meta-analysis, we aimed to systematically examine the relationship between body mass index and major adverse cardiovascular events in acute coronary syndrome patients and to provide theoretical guidance for body weight management in these patients. Methods: A comprehensive analysis of applicable research published between 2008 and 2021 was conducted using the PubMed, Cochrane, Web of Science, Wanfang, and CNKI databases. Extracted odds ratios from the randomized-controlled studies were pooled using fixed-effects meta-analysis. Publication bias was addressed through evaluation methods such as funnel plot or sensitivity analysis. Results: Ten studies with a total of 58,992 individuals were included. The consequences of this meta-analysis confirmed that, compared to normal body mass index, patients with acute coronary syndrome significantly increased the risk of major adverse cardiovascular events (odds ratio= 1.20; 95% confidence interval: 1.12-1.29, p<0.001). Conclusion: Patients with acute coronary syndrome being overweight or obese significantly increased the risk of major adverse cardiovascular events compared to those with normal body mass index. The results suggest that patients may focus on weight management to reduce the risk of major adverse cardiovascular events in acute coronary syndrome.