A Study of Prevalence of Thyroid Disorders in Patients with Type 2 Diabetes Mellitus

Abstract

Context: Thyroid disorders are very common in the general population and it is second only to diabetes as the most common condition to affect the endocrine system. In this study we try to observe the prevalence of type of thyroid dysfunction in patients with T2DM. Aims: Prevalence of thyroid dysfunction in patients with T2DM and its effect on glycemic parameters. Prevalence of autoimmune thyroid disorder in patients with T2DM. Settings and Design: This study included adults having Type 2 DM. Patients were explained about the nature of study and consent was taken. Methods and Material: Clearance was taken from the ethics committee. All participants who met the inclusion criteria were subjected to detailed clinical examination and relevant investigation. Statistical analysis: Chi-square test Results: 234 patients, 112 male and 122 female were included in the study. The mean BMI was high (26.21 ± 3.13 kg/m2). The mean HbA1c was 8.81 ± 1.96%, while mean HbA1c in patients with both T2DM and thyroid dysfunction was 9.68±1.35%. Thyroid dysfunction was found in 84 cases (35.8%) out of which most common thyroid abnormality was Overt Hypothyroidism (61.9%) followed by Sub-clinical hypothyroidism (27.3%). Out of 84 cases with thyroid dysfunction Anti-TPO was found positive in 45 cases (53.5%) and the most common thyroid dysfunction associated with positive Anti-TPO was subclinical hypothyroidism (44%). Conclusion: The study shows high prevalence of thyroid dysfunction among patients with T2DM and its association with poor glycemic control. The study also shows the prevalence of Anti-TPO among patients and its significant correlation with thyroid dysfunction.