Tandem high-dose multiagent chemotherapy followed by autologous stem cell transplantation in children with high-risk neuroblastoma

Abstract

The improvement of treatment outcomes for children with high-risk neuroblastoma is one of the most significant challenges in current pediatric oncology/hematology practice. Treatment outcomes in these patients need to be improved, both in terms of achieving remission and in terms of toxicity profile. At the present time, a number of approaches have been adopted to achieve better outcomes, including the intensification of treatment by using tandem high-dose multiagent chemotherapy followed by autologous hematopoietic stem cell transplantation as a part of treatment. Tandem high-dose chemotherapy with autologous hematopoietic stem cell transplantation has been shown to be effective and safe in several studies. The purpose of this literature review is to present research data showing the feasibility and safety of this treatment strategy in practice.