Intracellular signaling involved in the programmed neutrophil cell death leading to the release of extracellular DNA traps in thrombus formation-Reference-Cited by-同舟云学术

Intracellular signaling involved in the programmed neutrophil cell death leading to the release of extracellular DNA traps in thrombus formation

Published:2024-07-23 Issue:2 Volume:23 Page:222-230
ISSN:2414-9314
Container-title:Pediatric Hematology/Oncology and Immunopathology
language:
Short-container-title:Voprosy gematologii/onkologii i immunopatologii v pediatrii

Author:

Sveshnikova A. N.¹^ORCID,Adamanskaya E. A.²^ORCID,Korobkina Yu.-D. D.³^ORCID,Panteleev M. A.¹^ORCID

Affiliation:

1. Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation; M.V. Lomonosov Moscow State University; Center for Theoretical Problems of Physical and Chemical Pharmacology, Russian Academy of Sciences

2. Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation; Center for Theoretical Problems of Physical and Chemical Pharmacology, Russian Academy of Sciences

3. Center for Theoretical Problems of Physical and Chemical Pharmacology, Russian Academy of Sciences

Abstract

The formation of extracellular DNA traps by neutrophils, or NETs (neutrophil extracellular traps) plays an essential role in many pathological processes related to hematological, oncological, and immunological diseases. This mechanism of the programmed cell death of neutrophils and other leukocytes appears to be also involved in the pathogenesis of thrombosis and thrombotic complications of a variety of disorders. In this review, we discuss the pathways of intracellular signaling leading to neutrophil activation in thrombosis and hemostasis. Even though the biochemical reactions in a cell are quite well investigated, the regulation of activity of specific proteins involved in NETosis, such as NADPH oxidase (NOX) and protein-arginine deiminase (PAD4), requires further investigation. Current approaches to the pharmacological modulation of NETosis are also specifically addressed here.

Publisher

Fund Doctors, Innovations, Science for Children

Reference84 articles.

1. Palacios-Acedo A.L., Mège D., Crescence L., Dignat-George F., Dubois C., Panicot-Dubois L. Platelets, Thrombo-Inflammation, and Cancer: Collaborating With the Enemy. Front Immunol 2019, 10: 1805. DOI: 10.3389/fimmu.2019.01805

2. Thålin C., Hisada Y., Lundström S., Mackman N., Wallén H. Neutrophil Extracellular Traps: Villains and Targets in Arterial, Venous, and Cancer-Associated Thrombosis. Arterioscler Thromb Vasc Biol 2019, 39 (9): 1724–38. DOI: 10.1161/ATVBAHA.119.312463

3. Адаманская Е.А., Коробкина, Ю.Д., Юшкова E.B., Свешникова А.Н. Повышенное образование ДНК-ловушек нейтрофилов и особенности их хемотаксиса в образцах крови пациентов с раком молочной железы. Тезисы докладов Международной научной конференции, посвященной 50-летию института (Республика Беларусь, Минск, 26–27 октября 2023 г.). Минск, 2023. [Adamanskaya E.A., Korobkina Yu.-D.D., Yushkova E.V., Sveshnikova A.N. Increased formation of neutrophil DNA traps and the characteristics of neutrophil chemotaxis in blood samples from patients with breast cancer. Abstracts for International Scientific Conference to Mark the 50th Anniversary of the Institute (Republic of Belarus, Minsk, 26–27 October 2023). Minsk, 2023. (In Russ.)].

4. Caudrillier A., Kessenbrock K., Gilliss B.M., Nguyen J.X., Marques M.B., Monestier M., et al. Platelets Induce Neutrophil Extracellular Traps in Transfusion-Related Acute Lung Injury. J Clin Invest 2012, 122: 2661–71. DOI: 10.1172/JCI61303

5. Golas A., Parhi P., Dimachkie Z.O., Siedlecki C.A., Vogler E.A. Surface-Energy Dependent Contact Activation of Blood Factor XII. Biomaterials 2010, 31: 1068–79. DOI: 10.1016/j.biomaterials.2009.10.039