Leptomeningeal canceromatosis in patient with parameningeal rhabdomyosarcoma

Abstract

The development of leptomeningeal carcinomatosis (LC) is quite a frequent event during a rhabdomyosarcoma with parameningeal localization, usually known as a parameningeal rhabdomyosarcoma (PM RMS). However, the diagnosis and treatment of this kind of progression are still difficult for pediatricians and pediatric oncologists due to the small absolute number of PM RMS patients, which makes it impossible to accumulate sufficient clinical experience, as well as due to the absence of a pathognomonic clinical picture and a standardized specific therapy. The article describes 3 clinical cases of LC during PM RMS and provides an overview of existing literature focusing on this problem. Parents patients agreed to use personal data in research and publications.