The potential of impulse oscillometry in lung function assessment in children after allogeneic hematopoietic stem cell transplantation

Abstract

   The article analyzes the potential of using impulse oscillometry in the diagnosis of respiratory disorders in children with oncological and hematological diseases after allogeneic hematopoietic stem cell transplantation (HSCT). The study was approved by the Independent Ethics Committee and the Scientific Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation. A comparative analysis of parameters of impulse oscillometry and spirometry before and on Days 30, 90, 180 and 360 after HSCT was carried out. It was revealed that pulmonary ventilation function impairments are quite common in this group of patients, worsening significantly by month 3 of follow-up. An increase in reactance at a frequency of 5 Hz is one of the earliest signs of impaired respiratory function, which can be used for timely diagnosis of pulmonary complications after allogeneic HSCT.