Flow cytometry in acute leukemia diagnostics. Guidelines of Russian-Belarusian multicenter group for pediatric leukemia studies-Reference-Cited by-同舟云学术

Flow cytometry in acute leukemia diagnostics. Guidelines of Russian-Belarusian multicenter group for pediatric leukemia studies

Published:2023-02-14 Issue:1 Volume:22 Page:165-177
ISSN:2414-9314
Container-title:Pediatric Hematology/Oncology and Immunopathology
language:
Short-container-title:Voprosy gematologii/onkologii i immunopatologii v pediatrii

Author:

Popov A. M.¹^ORCID,Verzhbitskaya T. Yu.²^ORCID,Movchan L. V.³,Demina I. A.¹,Mikhailova E. V.¹,Semchenkova A. A.¹,Permikin Zh. V.²,Shman T. V.³,Karachunskiy A. I.¹^ORCID,Novichkova G. A.¹^ORCID

Affiliation:

1. The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

2. Regional Children's Clinical Hospital No.1

3. Belarusian Research Center for Pediatric Oncology, Hematology and Immunology

Abstract

Flow cytometry is one of the key technologies for acute leukemia (AL) diagnostics. Nevertheless, lack of technological standards hampers implementation of immunophenotyping data in treatment protocols. Earlier our group published the acute lymphoblastic leukemia diagnostic standards. In this paper, we present the updated guidelines for initial immunophenotyping of ALs. This wellharmonized approach includes recommendations for monoclonal antibodies choice, sample preparation, cytometer setup, data analysis and interpretation as well as for the report writing. These guidelines allows application of diagnostic flow cytometric studies in all types of AL.

Publisher

Fund Doctors, Innovations, Science for Children

Subject

Oncology,Hematology,Immunology,Immunology and Allergy,Pediatrics, Perinatology and Child Health

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