Affiliation:
1. Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
Abstract
This paper presents a literature review of nephroblastoma molecular biology. In this article, we explored protein-coding genes in which mutations are the most common cause of Wilms’ tumor. We analyzed the role of these genes both in normal renal development and in Wilms’ tumorigenesis. Our special attention was focused on the embryonic development of the kidneys and how mutations in certain genes can disrupt normal nephrogenesis leading to the emergence of nephroblastoma.
Publisher
Fund Doctors, Innovations, Science for Children
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