Affiliation:
1. Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
Abstract
This paper presents a literature review of nephroblastoma molecular biology. In this article, we explored protein-coding genes in which mutations are the most common cause of Wilms’ tumor. We analyzed the role of these genes both in normal renal development and in Wilms’ tumorigenesis. Our special attention was focused on the embryonic development of the kidneys and how mutations in certain genes can disrupt normal nephrogenesis leading to the emergence of nephroblastoma.
Publisher
Fund Doctors, Innovations, Science for Children
Subject
Oncology,Hematology,Immunology,Immunology and Allergy,Pediatrics, Perinatology and Child Health
Reference40 articles.
1. Siegel R.L., Miller K.D., Fuchs H.E., Jemal A. Cancer statistics, 2022. CA Cancer J Clin 2022; 72 (1): 7–33.
2. Hohenstein P., PritchardJones K., Charlton J. The yin and yang of kidney development and Wilms' tumors. Genes Dev 2015; 29 (5): 467–82.
3. Kuznetsov S.L., Mushkambarov N.N. Gistologiya, tsitologiya i embriologiya: Uchebnik. 3-e izd., ispr. i dop. M.: OOO «Izdatel'stvo «Meditsinskoe informatsionnoe agentstvo»; 2016.
4. [Electronic resource] WT1 WT1 transcription factor [Homo sapiens (human)]. URL: https://www.ncbi.nlm.nih.gov/gene/7490 (accessed 30.10.2023).
5. Coppes M.J., Williams B.R. The molecular genetics of Wilms tumor. Cancer Invest 1994; 12 (1): 57–65.