Methylation changes and pathways affected in preterm birth: a role for SLC6A3 in neurodevelopment-Reference-Cited by-同舟云学术

Methylation changes and pathways affected in preterm birth: a role for SLC6A3 in neurodevelopment

Published:2018-01 Issue:1 Volume:10 Page:91-103
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Arpón Ana¹²,Milagro Fermín I¹²³,Laja Ana⁴,Segura Víctor⁵,de Pipaón Miguel Sáenz⁶⁷⁸,Riezu-Boj José-Ignacio¹²⁹,Alfredo Martínez J¹²³⁹¹⁰

Affiliation:

1. Department of Nutrition, Food Sciences & Physiology, Universidad de Navarra, Irunlarrea 1, 31008 Pamplona, Spain

2. Centre for Nutrition Research, Universidad de Navarra, Irunlarrea 1, 31008 Pamplona, Spain

3. Spanish Biomedical Research Centre in Physiopathology of Obesity & Nutrition (CIBERobn), Institute of Health Carlos III, Madrid, Spain

4. Department of Pharmaceutical & Health Sciences, Faculty of Pharmacy, CEU San Pablo University, Madrid, Spain

5. Unit of Bioinformatics, Centre for Applied Medical Research (CIMA), Universidad de Navarra, Pamplona, Spain

6. Neonatology Department, Hospital Universitario de la Paz, Madrid, Spain

7. Instituto de Salud Carlos III, Red de Salud Materno Infantil y Desarrollo (SAMID), Madrid, Spain

8. Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain

9. Digestive disease and Nutrition group, Navarra Institute for Health Research (IdiSNa), Pamplona, Spain

10. Madrid Institute of Advanced Studies (IMDEA), IMDEA Food, Madrid, Spain

Abstract

Aim: To analyze whether preterm newborns show differences in methylation patterns in comparison to full-term newborns in white blood cells. Patients & methods: Anthropometrical, biochemical features and methylation levels of preterm newborns (n = 24) and full-term newborns (n = 22) recruited in La Paz University Hospital (Spain) were assessed at 12 months of gestational age, whereas Bayley Scale of Infant Development was evaluated at 24/36 months. Results: From all the statistically significant CpGs, methylation levels of cg00997378 (SLC6A3 gene) showed the highest differences (p < 0.0001), being associated with prematurity risk factors. Conclusion: SLC6A3 methylation, previously related to attention-deficit/hyperactivity disorder, neuronal function and behavior, might be a potential epigenetic biomarker with value in the early diagnosis and management of neurodevelopmental diseases in newborns.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2017-0082

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