Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts-Reference-Cited by-同舟云学术

Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts

Published:2018-01 Issue:1 Volume:10 Page:27-42
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Sharp Gemma C¹²³,Arathimos Ryan¹²,Reese Sarah E⁴,Page Christian M⁵⁶,Felix Janine⁷⁸⁹,Küpers Leanne K¹²¹⁰,Rifas-Shiman Sheryl L¹¹,Liu Chunyu¹²¹³¹⁴,Burrows Kimberley¹²,Zhao Shanshan⁴,Magnus Maria C¹²⁵,Duijts Liesbeth⁷¹⁵¹⁶,Corpeleijn Eva¹⁰,DeMeo Dawn L¹⁷,Litonjua Augusto¹⁷,Baccarelli Andrea¹⁸,Hivert Marie-France¹¹¹⁹,Oken Emily¹¹,Snieder Harold¹⁰,Jaddoe Vincent⁷⁸⁹,Nystad Wenche⁵,London Stephanie J⁴,Relton Caroline L¹²,Zuccolo Luisa¹²,

Affiliation:

1. MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK

2. School of Social & Community Medicine, University of Bristol, Bristol, BS8 2BN, UK

3. School of Oral & Dental Sciences, University of Bristol, Bristol, UK

4. Division of Intramural Research, Department of Health & Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA

5. Division for Mental & Physical Health, Department of Non-Communicable Diseases, Norwegian Institute of Public Health, Oslo, Norway

6. Oslo Centre for Biostatistics & Epidemiology, Oslo University Hospital, Oslo, Norway

7. The Generation R Study Group, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands

8. Department of Epidemiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands

9. Department of Pediatrics, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands

10. Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

11. Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA

12. The Framingham Heart Study, Framingham, MA, USA

13. The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, & Blood Institute, Bethesda, MD, USA

14. Department of Biostatistics, Boston University School of Public Health, 715 Albany St, Boston, MA, USA

15. Department of Pediatrics, Division of Respiratory Medicine & Allergology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands

16. Department of Pediatrics, Division of Neonatology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands

17. Channing Division of Network Medicine, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, USA

18. Laboratory of Precision Environmental Biosciences, Columbia University Mailman School of Public Health, New York, NY, USA

19. Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA

Abstract

Aim: Alcohol consumption during pregnancy is sometimes associated with adverse outcomes in offspring, potentially mediated by epigenetic modifications. We aimed to investigate genome-wide DNA methylation in cord blood of newborns exposed to alcohol in utero. Materials & methods: We meta-analyzed information from six population-based birth cohorts within the Pregnancy and Childhood Epigenetics consortium. Results: We found no strong evidence of association at either individual CpGs or across larger regions of the genome. Conclusion: Our findings suggest no association between maternal alcohol consumption and offspring cord blood DNA methylation. This is in stark contrast to the multiple strong associations previous studies have found for maternal smoking, which is similarly socially patterned. However, it is possible that a combination of a larger sample size, higher doses, different timings of exposure, exploration of a different tissue and a more global assessment of genomic DNA methylation might show evidence of association.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2017-0095

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