Genetic risk factors for drug-induced liver injury in rheumatoid arthritis patients using low-dose methotrexate-Reference-Cited by-同舟云学术

Genetic risk factors for drug-induced liver injury in rheumatoid arthritis patients using low-dose methotrexate

Published:2013-01 Issue:1 Volume:14 Page:63-73
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Dávila-Fajardo Cristina Lucía¹,Swen Jesse J²,Cabeza Barrera José¹,Guchelaar Henk-Jan³

Affiliation:

1. Department of Clinical Pharmacy, San Cecilio University Hospital Granada, Spain

2. Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, PO Box 9600, NL 2300 RC Leiden, The Netherlands

3. Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, PO Box 9600, NL 2300 RC Leiden, The Netherlands.

Abstract

Low-dose methotrexate (MTX) is part of the mainstay of rheumatoid arthritis treatment. Hepatotoxicity is among the most feared side effects of low-dose MTX and is associated with increased morbidity. At present, histological evaluation of liver biopsies is the gold standard to retrospectively diagnose MTX-induced liver damage. Genetic markers present an interesting opportunity to pre-emptively identify patients at risk for MTX-induced hepatotoxicity. Here, we will review the literature on candidate genetic markers for the risk of MTX-induced hepatotoxicity. These candidate genetic markers include polymorphisms in the gene encoding the enzyme MTHFR.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pgs.12.183

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