Transcutaneous electrical nerve stimulation and cervical joint manipulation on pressure pain threshold

Abstract

Aim: Transcutaneous electrical nerve stimulation (TENS) and cervical joint manipulation (CJM) are often used for pain treatment. Methods: A total of 144 healthy subjects will be randomly allocated into four groups: active TENS and CJM, placebos TENS and CJM, placebo TENS and active CJM, active TENS and placebo CJM. TENS will be applied for 20 min followed by CJM. All subjects will be assessed before, during and after interventions, using a digital pressure algometer. Discussion: This is the first study to assess the combined effects of TENS and CJM on pressure pain threshold in healthy individuals. It is possible that both methods combined can enhance the hypoalgesic effect because they activate different analgesic pathways. Study registration: NCT03531541 (ClinicalTrials.gov).