Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer-Reference-Cited by-同舟云学术

Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer

Published:2014-05 Issue:7 Volume:10 Page:1187-1202
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Blanco-Calvo Moisés¹,Tarrío Nuria²,Reboredo Margarita³,Haz-Conde Mar¹,García Jorge³,Quindós María³,Figueroa Angélica¹,Antón-Aparicio Luis¹³,Calvo Lourdes³,Valladares-Ayerbes Manuel¹³

Affiliation:

1. Translational Cancer Research Department, La Coruña Biomedical Research Institute (INIBIC), Carretera del Pasaje s/n, 15006 La Coruña, Spain

2. Clinical Biochemistry Department, Marqués de Valdecilla University Hospital, Avenida Valdecilla 25, 39008 Santander, Spain

3. Clinical Oncology Department, La Coruña University Hospital (CHUAC), As Xubias 84, 15006 La Coruña, Spain

Abstract

ABSTRACT: Aim: To analyze GDF15 and MMP7 serum levels as diagnostic biomarkers in gastric cancer (GC) patients. The prognostic value of GDF15 and MMP7 serum levels in combination with miR-200c blood expression was also analyzed. Patients & methods: Fifty-two GC and 23 control samples were included. Results: GDF15 and MMP7 proved to be powerful tools for GC diagnosis. Increased levels of GDF15 and MMP7 were associated with shorter progression-free survival and overall survival in univariate analysis. In multivariate analysis, the combination of high levels of GDF15, MMP7 and miR-200c was an independent predictor for death (p = 0.033). Conclusion: GDF15 and MMP7 serum levels have diagnostic value for GC. The combination marker formed by GDF15, MMP7 and miR-200c is indicative of adverse evolution in GC patients.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon.13.263

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